Germline-encoded amino acids in the αβ T-cell receptor control thymic selection

James P. Scott-Browne (), Janice White, John W. Kappler, Laurent Gapin and Philippa Marrack ()
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James P. Scott-Browne: National Jewish Health and University of Colorado Denver, Denver, Colorado 80206, USA
Janice White: National Jewish Health and University of Colorado Denver, Denver, Colorado 80206, USA
John W. Kappler: National Jewish Health and University of Colorado Denver, Denver, Colorado 80206, USA
Laurent Gapin: National Jewish Health and University of Colorado Denver, Denver, Colorado 80206, USA
Philippa Marrack: National Jewish Health and University of Colorado Denver, Denver, Colorado 80206, USA

Nature, 2009, vol. 458, issue 7241, 1043-1046

Abstract: T-cell receptors An αβ T-cell response depends on the recognition of antigen plus major histocompatibility complex (MHC) proteins by its antigen receptor (TCR). Scott-Browne et al. present evidence that TCR genes encode inherent specificity for MHC molecules.

Date: 2009
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DOI: 10.1038/nature07812

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