Natural variation in a neural globin tunes oxygen sensing in wild Caenorhabditis elegans

Annelie Persson, Einav Gross, Patrick Laurent, Karl Emanuel Busch, Hugo Bretes and Mario de Bono ()
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Annelie Persson: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Einav Gross: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Patrick Laurent: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Karl Emanuel Busch: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Hugo Bretes: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Mario de Bono: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK

Nature, 2009, vol. 458, issue 7241, 1030-1033

Abstract: Oxygen sensors: neural globin tunes in The roundworm, Caenorhabditis elegans, alters its behaviour in response to changes in ambient oxygen by employing atypical soluble guanylate cyclases as oxygen sensors. Here, Persson et al. confirm that the soluble guanylate cyclase, GCY-35, responds to increased oxygen and further show that a neural globin, GLB-5, is involved in sensing reduced oxygen. The behavioural response to GLB-5 activation involves a neuropeptide receptor, NPR-1, and both glb-5 and npr-1 show natural variation amongst different C. elegans strains. This work provides confirmation that globins can act as O2 sensors in metazoans, and that these O2 responses can be tuned in a narrow dynamic range.

Date: 2009
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DOI: 10.1038/nature07820

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