Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division

F. Coumailleau, M. Fürthauer (), J. A. Knoblich and M. González-Gaitán ()
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F. Coumailleau: University of Geneva, 30 Quai Ernest-Ansermet, 1211 Geneva 4, Switzerland
M. Fürthauer: University of Geneva, 30 Quai Ernest-Ansermet, 1211 Geneva 4, Switzerland
J. A. Knoblich: Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3, 1030 Vienna, Austria
M. González-Gaitán: University of Geneva, 30 Quai Ernest-Ansermet, 1211 Geneva 4, Switzerland

Nature, 2009, vol. 458, issue 7241, 1051-1055

Abstract: Directional Notch/Delta traffic in cell division In Drosophila melanogaster, the sensory organ precursor cells (SOP) undergo asymmetric division resulting in a posterior pIIa cell and an anterior pIIb cell that further divide to create daughters with different cell fates. SOP division is dependent on signalling by the transmembrane receptor Notch and its receptor, Delta. Notch and Delta are expressed in pIIa and pIIb cells, but Notch signalling is activated only in the pIIa cell. In this study, Coumailleau et al. provide a mechanistic basis for differential signalling of Notch. They show that in SOP, Notch and Delta traffic to special endosomes marked by the protein SARA. During cell division, these endosomes move to the central spindle and are then asymmetrically segregated into the pIIa cell where Notch signalling is activated. Hence asymmetric trafficking of Notch/Delta containing endosomes increases Notch signalling in pIIa cells and decreasing it in pIIb cells.

Date: 2009
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DOI: 10.1038/nature07854

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