Temporally precise in vivo control of intracellular signalling

Raag D. Airan, Kimberly R. Thompson, Lief E. Fenno, Hannah Bernstein and Karl Deisseroth ()
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Raag D. Airan: Department of Bioengineering,
Kimberly R. Thompson: Department of Bioengineering,
Lief E. Fenno: Department of Bioengineering,
Hannah Bernstein: Department of Bioengineering,
Karl Deisseroth: Department of Bioengineering,

Nature, 2009, vol. 458, issue 7241, 1025-1029

Abstract: Intracellular signalling: all in good time Ion channels driven by light have provided electrophysiologists with unprecedented control over the activity state of neurons. Here, Deisseroth and colleagues introduce new molecules that offer a similar level of control over signalling pathways to biochemists. Opsin/GPCR chimaeras were engineered, enabling the authors to modulate G-protein activity via light, which in turn could influence neuronal firing. Expressed in vivo, activating these molecules could drive conditioned place preference in behaving mice.

Date: 2009
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DOI: 10.1038/nature07926

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