Discovery of insect and human dengue virus host factors

October M. Sessions, Nicholas J. Barrows, Jayme A. Souza-Neto, Timothy J. Robinson, Christine L. Hershey, Mary A. Rodgers, Jose L. Ramirez, George Dimopoulos, Priscilla L. Yang, James L. Pearson () and Mariano A. Garcia-Blanco ()
Additional contact information
October M. Sessions: Department of Molecular Genetics and Microbiology,
Nicholas J. Barrows: Center for RNA Biology,
Jayme A. Souza-Neto: Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, Maryland 21205-2179, USA
Timothy J. Robinson: Department of Molecular Genetics and Microbiology,
Christine L. Hershey: Harvard Medical School, Boston, Massachusetts 02115, USA
Mary A. Rodgers: Harvard Medical School, Boston, Massachusetts 02115, USA
Jose L. Ramirez: Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, Maryland 21205-2179, USA
George Dimopoulos: Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, Maryland 21205-2179, USA
Priscilla L. Yang: Harvard Medical School, Boston, Massachusetts 02115, USA
James L. Pearson: Department of Molecular Genetics and Microbiology,
Mariano A. Garcia-Blanco: Department of Molecular Genetics and Microbiology,

Nature, 2009, vol. 458, issue 7241, 1047-1050

Abstract: Dengue fever virus infectivity Dengue fever is endemic in many countries in South and Southeast Asia, Africa and South America, and elsewhere it is an emerging threat. It is caused by one of four dengue viruses — DENV-1, 2, 3 and 4 — transmitted by Aedes sp. mosquitoes; there is no approved vaccine and no effective specific therapy. The dengue viruses are compact flaviviruses likely to require a large number of host factors, and knowledge of those factors could lead to the discovery of potential targets for drugs and new vector control strategies. Now by using a high-throughput RNAi screening approach in DENV-2-infected Drosophila cells — Drosophila is related to the vector species and more amenable to the tools of genomics — more than a hundred candidate dengue virus host factors have been identified, many of them also acting as host factors in human cells.

Date: 2009
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DOI: 10.1038/nature07967

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