Toxin B is essential for virulence of Clostridium difficile

Dena Lyras, Jennifer R. O’Connor, Pauline M. Howarth, Susan P. Sambol, Glen P. Carter, Tongted Phumoonna, Rachael Poon, Vicki Adams, Gayatri Vedantam, Stuart Johnson, Dale N. Gerding and Julian I. Rood ()
Additional contact information
Dena Lyras: Australian Bacterial Pathogenesis Program and,
Jennifer R. O’Connor: Australian Bacterial Pathogenesis Program and,
Pauline M. Howarth: Australian Bacterial Pathogenesis Program and,
Susan P. Sambol: Medical Service and Research Service, Hines VA Hospital, Hines, Illinois 60141, USA, and Infectious Disease Section, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153, USA
Glen P. Carter: Australian Bacterial Pathogenesis Program and,
Tongted Phumoonna: Australian Bacterial Pathogenesis Program and,
Rachael Poon: Australian Bacterial Pathogenesis Program and,
Vicki Adams: Australian Bacterial Pathogenesis Program and,
Gayatri Vedantam: Medical Service and Research Service, Hines VA Hospital, Hines, Illinois 60141, USA, and Infectious Disease Section, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153, USA
Stuart Johnson: Medical Service and Research Service, Hines VA Hospital, Hines, Illinois 60141, USA, and Infectious Disease Section, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153, USA
Dale N. Gerding: Medical Service and Research Service, Hines VA Hospital, Hines, Illinois 60141, USA, and Infectious Disease Section, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153, USA
Julian I. Rood: Australian Bacterial Pathogenesis Program and,

Nature, 2009, vol. 458, issue 7242, 1176-1179

Abstract: The A to B of C. diff toxins Clostridium difficile infections, often associated with antibiotic therapy, are a rapidly emerging hazard in hospitals worldwide. The bacterium produces two toxins, A and B, and studies with purified toxins have led to the common perception that toxin A is the main cause of pathology. Now a new study, in which bacterial strains lacking each toxin were tested in an animal model, suggests that in fact toxin B is essential for C. difficile virulence, and would be a more promising potential target for therapeutic or preventative measures.

Date: 2009
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DOI: 10.1038/nature07822

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