The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

Beom Seok Park, Dong Hyun Song, Ho Min Kim, Byong-Seok Choi, Hayyoung Lee and Jie-Oh Lee ()
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Beom Seok Park: Department of Chemistry and,
Dong Hyun Song: Department of Chemistry and,
Ho Min Kim: Department of Chemistry and,
Byong-Seok Choi: Department of Chemistry and,
Hayyoung Lee: School of Bioscience & Biotechnology, Chungnam National University, Daejeon, 305-764, Korea
Jie-Oh Lee: Department of Chemistry and,

Nature, 2009, vol. 458, issue 7242, 1191-1195

Abstract: Innate immunity: LPS recognition This paper describes the crystal structure of TLR4-MD-2-LPS, the complex between Toll-like receptor 4, myeloid differentiation factor 2 and lipopolysaccharide (LPS).The structure reveals how the TLR4-MD-2-receptor complex recognizes LPS, a major component of the outer membrane of Gram negative bacteria that induces strong inflammatory responses by activating the human innate immune system. This work throws light on the important role of Toll-like receptor in innate immunity.

Date: 2009
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DOI: 10.1038/nature07830

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