Embryonic stem cells use ZFP809 to silence retroviral DNAs

Daniel Wolf and Stephen P. Goff ()
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Daniel Wolf: Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, HHSC 1310, 701 West 168th Street, New York, New York 10032, USA
Stephen P. Goff: Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, HHSC 1310, 701 West 168th Street, New York, New York 10032, USA

Nature, 2009, vol. 458, issue 7242, 1201-1204

Abstract: Retrovirus resistance in embryonic stem cells The gene responsible for the repression of retroviral DNAs in embryonic stem cells has now been identified — some 30 years after the phenomenon was first recognized. The gene encodes the zinc finger protein ZFP809. Expression of ZFP809 is sufficient to make even differentiated cells highly resistant to infection by the prototypical retrovirus Moloney murine leukaemia virus. The authors propose that ZFP809 evolved as a stem-cell-specific retroviral restriction factor, and therefore constitutes a new component of the intrinsic immune system of stem cells.

Date: 2009
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DOI: 10.1038/nature07844

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