Cytoplasmic functions of the tumour suppressor p53

Douglas R. Green () and Guido Kroemer ()
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Douglas R. Green: St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA
Guido Kroemer: Université Paris Sud, Paris 11,

Nature, 2009, vol. 458, issue 7242, 1127-1130

Abstract: Tumour suppressor p53 goes extranuclear The p53 tumour suppressor is inactivated by mutation in about half of all human cancers, and in many of the remainder the p53 pathway is inhibited in some way. p53 has been much studied of course, but mainly as a transcription factor and gene regulator. Douglas Green and Guido Kroemer present a review of an emerging area of p53 research, its role in the cytosol, where it triggers apoptosis and inhibits autophagy. These extranuclear actions — unknown until recently — contribute to p53's efficacy as a tumour suppressor, and may offer new targets for modulation of the p53 system.

Date: 2009
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DOI: 10.1038/nature07986

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