Haematopoietic stem cells depend on Gαs-mediated signalling to engraft bone marrow

Gregor B. Adams, Ian R. Alley, Ung-il Chung, Karissa T. Chabner, Nathaniel T. Jeanson, Cristina Lo Celso, Emily S. Marsters, Min Chen, Lee S. Weinstein, Charles P. Lin, Henry M. Kronenberg and David T. Scadden ()
Additional contact information
Gregor B. Adams: Center for Regenerative Medicine,
Ian R. Alley: Center for Regenerative Medicine,
Ung-il Chung: Endocrine Unit and,
Karissa T. Chabner: Center for Regenerative Medicine,
Nathaniel T. Jeanson: Center for Regenerative Medicine,
Cristina Lo Celso: Center for Regenerative Medicine,
Emily S. Marsters: Center for Regenerative Medicine,
Min Chen: National Institute for Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA
Lee S. Weinstein: National Institute for Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA
Charles P. Lin: Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Henry M. Kronenberg: Endocrine Unit and,
David T. Scadden: Center for Regenerative Medicine,

Nature, 2009, vol. 459, issue 7243, 103-107

Abstract: Showing stem cells the way Gαs signalling, a pathway previously not recognized as having a role in stem-cell biology, has been found to be critical in haematopoiesis in the developing fetus (without it cells do not transition from the fetal liver to the bone marrow) and in adult mice (without it cells do not engraft the bone marrow). Haematopoietic stem and progenitor cells that lack Gαs (the guanine-nucleotide-binding protein stimulatory α subunit) differentiate and undergo chemotaxis, but are unable to home in on their usual sites of action. Cholera toxin, a compound known to constitutively activate Gαs, enhanced stem-cell homing and engraftment in mice, suggesting that similar strategies could be used to improve the efficiency in transplants of human blood-forming stem cells. Currently massive numbers of blood-forming stem cells are used in clinical transplantation, in part due to inefficient homing and engraftment.

Date: 2009
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature07859 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:459:y:2009:i:7243:d:10.1038_nature07859

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature07859

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().