Compound vesicle fusion increases quantal size and potentiates synaptic transmission

Liming He, Lei Xue, Jianhua Xu, Benjamin D. McNeil, Li Bai, Ernestina Melicoff, Roberto Adachi and Ling-Gang Wu ()
Additional contact information
Liming He: National Institute of Neurological Disorders and Stroke, 35 Convent Drive, Building 35, Room 2B-1012, Bethesda, Maryland 20892, USA
Lei Xue: National Institute of Neurological Disorders and Stroke, 35 Convent Drive, Building 35, Room 2B-1012, Bethesda, Maryland 20892, USA
Jianhua Xu: National Institute of Neurological Disorders and Stroke, 35 Convent Drive, Building 35, Room 2B-1012, Bethesda, Maryland 20892, USA
Benjamin D. McNeil: National Institute of Neurological Disorders and Stroke, 35 Convent Drive, Building 35, Room 2B-1012, Bethesda, Maryland 20892, USA
Li Bai: National Institute of Neurological Disorders and Stroke, 35 Convent Drive, Building 35, Room 2B-1012, Bethesda, Maryland 20892, USA
Ernestina Melicoff: The University of Texas M. D. Anderson Cancer Center, 2121 West Holcombe Boulevard, Box 1100, Houston, Texas 77030, USA
Roberto Adachi: The University of Texas M. D. Anderson Cancer Center, 2121 West Holcombe Boulevard, Box 1100, Houston, Texas 77030, USA
Ling-Gang Wu: National Institute of Neurological Disorders and Stroke, 35 Convent Drive, Building 35, Room 2B-1012, Bethesda, Maryland 20892, USA

Nature, 2009, vol. 459, issue 7243, 93-97

Abstract: Vesicle fusion in synaptic potentiation Synaptic transmission is believed to function on a quantal mode, that is: through the fusion of one synaptic vesicle with the plasma membrane at a time. New work from Ling-Gang Wu's group at the National Institute of Neurological Disorders and Stroke now describes the fusion of synaptic vesicles with themselves, prior to the release of giant vesicles at a central synapse. The work implicates calcium-dependent synaptotagmin-2 in a mechanism that may apply to previously described compound vesicle fusion in non-neuronal, endocrine cells and at some more peripheral synapses. The study indicates that compound fusion is a significant contributor to synaptic potentiation, with implications for neuronal plasticity and disorders such as epilepsy.

Date: 2009
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DOI: 10.1038/nature07860

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