Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis

Christopher W. Wilson, Catherine T. Nguyen, Miao-Hsueh Chen, Jehn-Hsiahn Yang, Rhodora Gacayan, Jie Huang, Jau-Nian Chen and Pao-Tien Chuang ()
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Christopher W. Wilson: Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
Catherine T. Nguyen: Cell and Developmental Biology, University of California, Los Angeles, California 90095, USA
Miao-Hsueh Chen: Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
Jehn-Hsiahn Yang: Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
Rhodora Gacayan: Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
Jie Huang: Cell and Developmental Biology, University of California, Los Angeles, California 90095, USA
Jau-Nian Chen: Cell and Developmental Biology, University of California, Los Angeles, California 90095, USA
Pao-Tien Chuang: Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA

Nature, 2009, vol. 459, issue 7243, 98-102

Abstract: Hedgehog signalling: the evolution of Fused Hedgehog (Hh) signalling is important in development and disease. In this study Pao-Tien Chuang and colleagues study the function and evolution of Fused (Fu), which is required for Hh signalling in Drosophila but not in mice. They find that the function of Fu has changed over evolution. In mice, Fu is required for the formation of motile cilia. In contrast, in zebrafish, Fu is required for both Hh signalling and cilia formation thus representing an evolutionary intermediate. This study reveals a novel pathway for cilia assembly and provides insight into the evolution of the Hh signalling cascade.

Date: 2009
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DOI: 10.1038/nature07883

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