Self-assembly of a nanoscale DNA box with a controllable lid

Ebbe S. Andersen, Mingdong Dong, Morten M. Nielsen, Kasper Jahn, Ramesh Subramani, Wael Mamdouh, Monika M. Golas, Bjoern Sander, Holger Stark, Cristiano L. P. Oliveira, Jan Skov Pedersen, Victoria Birkedal, Flemming Besenbacher, Kurt V. Gothelf () and Jørgen Kjems ()
Additional contact information
Ebbe S. Andersen: Danish National Research Foundation: Centre for DNA Nanotechnology,
Mingdong Dong: Danish National Research Foundation: Centre for DNA Nanotechnology,
Morten M. Nielsen: Danish National Research Foundation: Centre for DNA Nanotechnology,
Kasper Jahn: Danish National Research Foundation: Centre for DNA Nanotechnology,
Ramesh Subramani: Danish National Research Foundation: Centre for DNA Nanotechnology,
Wael Mamdouh: Danish National Research Foundation: Centre for DNA Nanotechnology,
Monika M. Golas: The Water and Salt Research Center, Institute of Anatomy,
Bjoern Sander: Stereology and EM Research Laboratory,
Holger Stark: Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D-37077 Göttingen, Germany
Cristiano L. P. Oliveira: Interdisciplinary Nanoscience Center,
Jan Skov Pedersen: Interdisciplinary Nanoscience Center,
Victoria Birkedal: Interdisciplinary Nanoscience Center,
Flemming Besenbacher: Danish National Research Foundation: Centre for DNA Nanotechnology,
Kurt V. Gothelf: Danish National Research Foundation: Centre for DNA Nanotechnology,
Jørgen Kjems: Danish National Research Foundation: Centre for DNA Nanotechnology,

Nature, 2009, vol. 459, issue 7243, 73-76

Abstract: DNA: boxing clever The use of DNA for the self-assembly of nanostructures has promising applications in chemistry, molecular computing and other emerging areas of nanotechnology. One approach that has shown particular promise is known as 'DNA origami'. Developed by Paul Rothemund, it involves a long single-stranded viral DNA sequence that is folded, with the help of short synthetic oligonucleotides, to create a planar nanostructure of arbitrary shape. Andersen et al. have now extended the DNA origami method into a third dimension by creating an addressable DNA box of 42×36×36 nm3 that can be opened in the presence of an externally supplied 'key'. Controlled access to the interior compartment of this DNA nanocontainer could yield several interesting applications, for example as a logic sensor for multiple-sequence signals or for the controlled release of nanocargos.

Date: 2009
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DOI: 10.1038/nature07971

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