Signals for change

Sadaf Shadan

Nature, 2009, vol. 459, issue 7244, 175-175

Abstract: Trypanosomes differentiation The sleeping sickness pathogen Trypanosoma brucei, like many other parasites, has a complex life cycle involving insect and mammalian hosts. It has been long known that differentiation from the human blood to the tsetse-fly stage requires two signals, low temperature and citrate and/or cis-aconitate, but how these signals were perceived was not clear. Now the cell surface molecules that convey the environmental signal responsible for trypanosome differentiation have been identified as members of the trypanosome carboxylate-transporter family PAD. Significantly, it is the transmission-competent 'stumpy' forms of the blood-borne parasite — more robust than slender forms and competent to differentiate— that carry PAD proteins.

Date: 2009
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DOI: 10.1038/459175a

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