Detection and trapping of intermediate states priming nicotinic receptor channel opening

Nuriya Mukhtasimova, Won Yong Lee, Hai-Long Wang and Steven M. Sine ()
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Nuriya Mukhtasimova: Receptor Biology Laboratory
Won Yong Lee: Receptor Biology Laboratory
Hai-Long Wang: Receptor Biology Laboratory
Steven M. Sine: Receptor Biology Laboratory

Nature, 2009, vol. 459, issue 7245, 451-454

Abstract: Nicotinic receptor channel opening Acetylcholine receptors are pentameric ligand-gated ion channels that mediate rapid synaptic transmission. Each receptor possesses two agonist-binding sites, whose occupation leads to channel opening, but the precise molecular events that follow agonist binding are unclear. Here, Mukhtasimova et al. covalently lock receptors in conformations equivalent to agonist-bound states, and observe that each binding site initiates the formation of one of two 'primed' states, from which the channels are able to open and close.

Date: 2009
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DOI: 10.1038/nature07923

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