CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

Maximina H. Yun and Kevin Hiom ()
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Maximina H. Yun: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Kevin Hiom: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK

Nature, 2009, vol. 459, issue 7245, 460-463

Abstract: DNA repair: the chosen pathway Cells have two main DNA repair pathways, homologous recombination and end-joining, that were thought to function in different stages of the cell cycle. How the cell recognizes these stages and switches its predominant repair pathway is not well known. In this work, Maximina Yun and Kevin Hiom show that CtIP, a protein recently identified as a participant in the resection of broken DNA ends, serves to switch between these pathways. They show that as cells enter the cell stage that replicates DNA, CtIP undergoes a specific phosphorylation that recruits the breast cancer susceptibility protein, BRCA1, and this directs the cell to use homologous recombination.

Date: 2009
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DOI: 10.1038/nature07955

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