Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

Olaf Gross, Hendrik Poeck, Michael Bscheider, Catherine Dostert, Nicole Hannesschläger, Stefan Endres, Gunther Hartmann, Aubry Tardivel, Edina Schweighoffer, Victor Tybulewicz, Attila Mocsai, Jürg Tschopp and Jürgen Ruland ()
Additional contact information
Olaf Gross: III. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675 Munich, Germany
Hendrik Poeck: III. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675 Munich, Germany
Michael Bscheider: Ludwig-Maximilian Universität München
Catherine Dostert: University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
Nicole Hannesschläger: III. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675 Munich, Germany
Stefan Endres: Ludwig-Maximilian Universität München
Gunther Hartmann: Institute of Clinical Chemistry and Pharmacology, Universitätsklinikum Bonn
Aubry Tardivel: University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
Edina Schweighoffer: National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Victor Tybulewicz: National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Attila Mocsai: Semmelweis University School of Medicine
Jürg Tschopp: University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
Jürgen Ruland: III. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675 Munich, Germany

Nature, 2009, vol. 459, issue 7245, 433-436

Abstract: Beating anti-fungal defences Immunocompromised individuals are at high risk from fungal infection, yet the molecular mechanisms that govern host defence against fungi are not well understood. Gross et al. now show that Candida albicans infection in mice activates the NALP3 inflammasome via a mechanism involving Sky-induced production of reactive oxygen induced by the tyrosine kinase Syk.

Date: 2009
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DOI: 10.1038/nature07965

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