Unlocking the molecular secrets of sodium-coupled transporters

Harini Krishnamurthy, Chayne L. Piscitelli and Eric Gouaux
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Harini Krishnamurthy: Vollum Institute, Oregon Health and Science University
Chayne L. Piscitelli: Vollum Institute, Oregon Health and Science University
Eric Gouaux: Vollum Institute, Oregon Health and Science University

Nature, 2009, vol. 459, issue 7245, 347-355

Abstract: Abstract Transmembrane sodium-ion gradients provide energy that can be harnessed by 'secondary transporters' to drive the translocation of solute molecules into a cell. Decades of study have shown that such sodium-coupled transporters are involved in many physiological processes, making them targets for the treatment of numerous diseases. Within the past year, crystal structures of several sodium-coupled transporters from different families have been reported, showing a remarkable structural conservation between functionally unrelated transporters. These atomic-resolution structures are revealing the mechanism of the sodium-coupled transport of solutes across cellular membranes.

Date: 2009
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DOI: 10.1038/nature08143

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