The structure and function of G-protein-coupled receptors

Daniel M. Rosenbaum, Søren G. F. Rasmussen and Brian K. Kobilka
Additional contact information
Daniel M. Rosenbaum: Stanford University School of Medicine
Søren G. F. Rasmussen: Stanford University School of Medicine
Brian K. Kobilka: Stanford University School of Medicine

Nature, 2009, vol. 459, issue 7245, 356-363

Abstract: Abstract G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases. They are also fascinating molecules from the perspective of membrane-protein structure and biology. Great progress has been made over the past three decades in understanding diverse GPCRs, from pharmacology to functional characterization in vivo. Recent high-resolution structural studies have provided insights into the molecular mechanisms of GPCR activation and constitutive activity.

Date: 2009
References: Add references at CitEc
Citations: View citations in EconPapers (12)

Downloads: (external link)
https://www.nature.com/articles/nature08144 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:459:y:2009:i:7245:d:10.1038_nature08144

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature08144

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().