Emerging roles for lipids in shaping membrane-protein function

Rob Phillips, Tristan Ursell, Paul Wiggins and Pierre Sens
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Rob Phillips: California Institute of Technology
Tristan Ursell: California Institute of Technology
Paul Wiggins: Whitehead Institute of Biomedical Research
Pierre Sens: UMR Gulliver CNRS-ESPCI

Nature, 2009, vol. 459, issue 7245, 379-385

Abstract: Abstract Studies of membrane proteins have revealed a direct link between the lipid environment and the structure and function of some of these proteins. Although some of these effects involve specific chemical interactions between lipids and protein residues, many can be understood in terms of protein-induced perturbations to the membrane shape. The free-energy cost of such perturbations can be estimated quantitatively, and measurements of channel gating in model systems of membrane proteins with their lipid partners are now confirming predictions of simple models.

Date: 2009
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DOI: 10.1038/nature08147

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