Genetic analysis of radiation-induced changes in human gene expression

Denis A. Smirnov, Michael Morley, Eunice Shin, Richard S. Spielman and Vivian G. Cheung ()
Additional contact information
Denis A. Smirnov: Howard Hughes Medical Institute,
Michael Morley: The Children’s Hospital of Philadelphia,
Eunice Shin: The Children’s Hospital of Philadelphia,
Richard S. Spielman: Department of Genetics and,
Vivian G. Cheung: Howard Hughes Medical Institute,

Nature, 2009, vol. 459, issue 7246, 587-591

Abstract: Radiation-induced changes in gene expression We are regularly are exposed to radiation from environmental sources, and in medical procedures. To deal with radiation-induced damage, cells mount complex responses that rely on changes in gene expression. It has long been known that individuals vary in their sensitivity to radiation, and this variability is also seen at the gene expression level. Using radiation-induced changes in gene expression as quantitative traits, Smirnov et al. performed genetic linkage and association studies to map their regulators. The results provide new insights into the architecture of gene expression regulation in response to stress and have implications for basic and clinical understanding of how human cells respond to radiation.

Date: 2009
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/nature07940 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:459:y:2009:i:7246:d:10.1038_nature07940

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature07940

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().