Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment

Minsoo Kim, Michinaga Ogawa, Yukihiro Fujita, Yuko Yoshikawa, Takeshi Nagai, Tomohiro Koyama, Shinya Nagai, Anika Lange, Reinhard Fässler and Chihiro Sasakawa ()
Additional contact information
Minsoo Kim: International Research Center for Infectious Diseases
Michinaga Ogawa: Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
Yukihiro Fujita: Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
Yuko Yoshikawa: Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
Takeshi Nagai: Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
Tomohiro Koyama: Nippon Institute for Biological Science, 9-2221-1, Shinmachi, Ome, Tokyo 198-0024, Japan
Shinya Nagai: Nippon Institute for Biological Science, 9-2221-1, Shinmachi, Ome, Tokyo 198-0024, Japan
Anika Lange: Max-Planck Institute of Biochemistry, D-82152, Martinsried, Germany
Reinhard Fässler: Max-Planck Institute of Biochemistry, D-82152, Martinsried, Germany
Chihiro Sasakawa: International Research Center for Infectious Diseases

Nature, 2009, vol. 459, issue 7246, 578-582

Abstract: Bacterial hijack The intestinal epithelium undergoes rapid self-renewal and exfoliation from the basement membrane upon bacterial infection, a process that acts as a defence system against the pathogen. Despite this, many enteropathogenic bacteria can colonize the intestinal epithelium. Now a mechanism enabling pathogens to overcome this form of host defence has been identified. The Shigella virulence factor OspE — also found in many other enteropathogenic bacteria — reinforces host-cell-matrix adherence by interacting with integrin-linked kinase. This may suppress epithelial detachment and promote bacterial colonization within the intestinal epithelium. This suggests that small molecules that block OspE's hijack of integrin-linked kinase may be effective against some intestinal bacterial infections.

Date: 2009
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DOI: 10.1038/nature07952

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