Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors

Stéphane Rivière, Ludivine Challet, Daniela Fluegge, Marc Spehr and Ivan Rodriguez ()
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Stéphane Rivière: and National Center of Competence ‘Frontiers in Genetics’, University of Geneva
Ludivine Challet: and National Center of Competence ‘Frontiers in Genetics’, University of Geneva
Daniela Fluegge: Ruhr University
Marc Spehr: Ruhr University
Ivan Rodriguez: and National Center of Competence ‘Frontiers in Genetics’, University of Geneva

Nature, 2009, vol. 459, issue 7246, 574-577

Abstract: A new chemosensor family To date, four types of olfactory receptors have been described in mammals — odorant receptors, trace amine-associated receptors and vomeronasal type 1 and type 2 receptor superfamilies. Rivière et al. now report the identification of a additional novel olfactory receptor family, expressed by mouse vomeronasal sensory neurons. This family is encoded by five members of the formyl peptide receptor-related gene family (FPRs), which are otherwise known to mediate immune cell response to infection Cells expressing FPRs respond to ligands associated with disease and inflammation, which are excreted in urine, raising the possibility that FPRs detect the health status of individuals.

Date: 2009
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DOI: 10.1038/nature08029

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