NAADP mobilizes calcium from acidic organelles through two-pore channels

Peter J. Calcraft, Margarida Ruas, Zui Pan, Xiaotong Cheng, Abdelilah Arredouani, Xuemei Hao, Jisen Tang, Katja Rietdorf, Lydia Teboul, Kai-Ting Chuang, Peihui Lin, Rui Xiao, Chunbo Wang, Yingmin Zhu, Yakang Lin, Christopher N. Wyatt, John Parrington, Jianjie Ma, A. Mark Evans, Antony Galione and Michael X. Zhu ()
Additional contact information
Peter J. Calcraft: Centre for Integrative Physiology, College of Medicine and Veterinary Medicine, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, Scotland, UK
Margarida Ruas: University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
Zui Pan: UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA
Xiaotong Cheng: University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
Abdelilah Arredouani: University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
Xuemei Hao: College of Life Sciences, Peking University
Jisen Tang: Biochemistry, and Center for Molecular Neurobiology, The Ohio State University, 1060 Carmack Road, Columbus, Ohio 43210, USA
Katja Rietdorf: University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
Lydia Teboul: The Mary Lyon Centre, MRC Harwell, Oxfordshire OX11 0RD, UK
Kai-Ting Chuang: University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
Peihui Lin: UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA
Rui Xiao: Biochemistry, and Center for Molecular Neurobiology, The Ohio State University, 1060 Carmack Road, Columbus, Ohio 43210, USA
Chunbo Wang: Biochemistry, and Center for Molecular Neurobiology, The Ohio State University, 1060 Carmack Road, Columbus, Ohio 43210, USA
Yingmin Zhu: Biochemistry, and Center for Molecular Neurobiology, The Ohio State University, 1060 Carmack Road, Columbus, Ohio 43210, USA
Yakang Lin: Biochemistry, and Center for Molecular Neurobiology, The Ohio State University, 1060 Carmack Road, Columbus, Ohio 43210, USA
Christopher N. Wyatt: Centre for Integrative Physiology, College of Medicine and Veterinary Medicine, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, Scotland, UK
John Parrington: University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
Jianjie Ma: UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA
A. Mark Evans: Centre for Integrative Physiology, College of Medicine and Veterinary Medicine, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, Scotland, UK
Antony Galione: University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
Michael X. Zhu: Biochemistry, and Center for Molecular Neurobiology, The Ohio State University, 1060 Carmack Road, Columbus, Ohio 43210, USA

Nature, 2009, vol. 459, issue 7246, 596-600

Abstract: NAADP calcium mobilization Three signalling molecules cause increases in intracellular Ca2+ levels by triggering release of Ca2+ from intracellular stores due to their action on specific Ca2+-permeable receptors: inositol-1,4,5-trisphosphate binds to and opens the sarcoplasmic reticulum InsP3 receptor; cyclic ADP ribose activates the endoplasmic reticulum ryanodine receptor; but the molecular identity and location of the nicotinic acid adenine dinucleotide phosphate (NAADP) receptor is unknown. Here Calcraft et al. show that the lysosomal two-pore channel, TPC2, is the molecular target of NAADP.

Date: 2009
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/nature08030 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:459:y:2009:i:7246:d:10.1038_nature08030

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature08030

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().