Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma

Mara Compagno, Wei Keat Lim, Adina Grunn, Subhadra V. Nandula, Manisha Brahmachary, Qiong Shen, Francesco Bertoni, Maurilio Ponzoni, Marta Scandurra, Andrea Califano, Govind Bhagat, Amy Chadburn, Riccardo Dalla-Favera and Laura Pasqualucci ()
Additional contact information
Mara Compagno: Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center,
Wei Keat Lim: Joint Centers for Systems Biology,
Adina Grunn: Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center,
Subhadra V. Nandula: Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center,
Manisha Brahmachary: Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center,
Qiong Shen: Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center,
Francesco Bertoni: Laboratory of Experimental Oncology and Lymphoma Unit, Oncology Institute of Southern Switzerland (IOSI)
Maurilio Ponzoni: Pathology Unit, Unit of Lymphoid Malignancies, San Raffaele Scientific Institute
Marta Scandurra: Laboratory of Experimental Oncology and Lymphoma Unit, Oncology Institute of Southern Switzerland (IOSI)
Andrea Califano: Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center,
Govind Bhagat: Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center,
Amy Chadburn: Weill Medical College of Cornell University, New York, New York 10021, USA
Riccardo Dalla-Favera: Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center,
Laura Pasqualucci: Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center,

Nature, 2009, vol. 459, issue 7247, 717-721

Abstract: A20 link to B-cell lymphoma Two groups report in this issue that A20 protein, a negative regulator of NF-κB signalling pathways, is frequently inactivated in patients with B-cell lymphoma. Kato et al. show that cells lacking the A20 gene generate tumours in immunodeficient mice, and that tumour formation is suppressed when the protein is re-expressed. Compagno et al. show that A20 is inactivated in around 30% of patients with B-cell lymphoma. Both groups show that A20 protein suppresses cell growth in vitro and prompts cells to commit suicide.

Date: 2009
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DOI: 10.1038/nature07968

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