Frequent inactivation of A20 in B-cell lymphomas

Motohiro Kato, Masashi Sanada, Itaru Kato, Yasuharu Sato, Junko Takita, Kengo Takeuchi, Akira Niwa, Yuyan Chen, Kumi Nakazaki, Junko Nomoto, Yoshitaka Asakura, Satsuki Muto, Azusa Tamura, Mitsuru Iio, Yoshiki Akatsuka, Yasuhide Hayashi, Hiraku Mori, Takashi Igarashi, Mineo Kurokawa, Shigeru Chiba, Shigeo Mori, Yuichi Ishikawa, Koji Okamoto, Kensei Tobinai, Hitoshi Nakagama, Tatsutoshi Nakahata, Tadashi Yoshino, Yukio Kobayashi () and Seishi Ogawa ()
Additional contact information
Motohiro Kato: Cancer Genomics Project
Masashi Sanada: Cancer Genomics Project
Itaru Kato: Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Yasuharu Sato: Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan
Junko Takita: Cancer Genomics Project
Kengo Takeuchi: The Cancer Institute of Japanese Foundation for Cancer Research, Japan, 3-10-6 Ariake, Koto-ku, Tokyo 135-8550, Japan
Akira Niwa: Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Yuyan Chen: Cancer Genomics Project
Kumi Nakazaki: Cancer Genomics Project
Junko Nomoto: Hospital, and
Yoshitaka Asakura: Hospital, and
Satsuki Muto: Cancer Genomics Project
Azusa Tamura: Cancer Genomics Project
Mitsuru Iio: Cancer Genomics Project
Yoshiki Akatsuka: Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan
Yasuhide Hayashi: Gunma Children’s Medical Center, 779 Shimohakoda, Hokkitsu-machi, Shibukawa 377-8577, Japan
Hiraku Mori: Internal Medicine, Showa University Fujigaoka Hospital, 1-30, Fujigaoka, Aoba-ku, Yokohama-shi, Kanagawa 227-8501, Japan
Takashi Igarashi: Pediatrics,
Mineo Kurokawa: Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Shigeru Chiba: Cell Therapy and Transplantation Medicine, and,
Shigeo Mori: Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan
Yuichi Ishikawa: The Cancer Institute of Japanese Foundation for Cancer Research, Japan, 3-10-6 Ariake, Koto-ku, Tokyo 135-8550, Japan
Koji Okamoto: Early Oncogenesis Research Project, Research Institute, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
Kensei Tobinai: Hospital, and
Hitoshi Nakagama: Early Oncogenesis Research Project, Research Institute, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
Tatsutoshi Nakahata: Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Tadashi Yoshino: Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan
Yukio Kobayashi: Hospital, and
Seishi Ogawa: Cancer Genomics Project

Nature, 2009, vol. 459, issue 7247, 712-716

Abstract: A20 link to B-cell lymphoma Two groups report in this issue that A20 protein, a negative regulator of NF-κB signalling pathways, is frequently inactivated in patients with B-cell lymphoma. Kato et al. show that cells lacking the A20 gene generate tumours in immunodeficient mice, and that tumour formation is suppressed when the protein is re-expressed. Compagno et al. show that A20 is inactivated in around 30% of patients with B-cell lymphoma. Both groups show that A20 protein suppresses cell growth in vitro and prompts cells to commit suicide.

Date: 2009
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DOI: 10.1038/nature07969

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