Mechanism of differential control of NMDA receptor activity by NR2 subunits

Marc Gielen, Beth Siegler Retchless, Laetitia Mony, Jon W. Johnson and Pierre Paoletti ()
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Marc Gielen: Laboratoire de Neurobiologie, École Normale Supérieure, CNRS, 46 rue d’Ulm, 75005 Paris, France
Beth Siegler Retchless: University of Pittsburgh, A210 Langely Hall, Pittsburgh, Pennsylvania 15260, USA
Laetitia Mony: Laboratoire de Neurobiologie, École Normale Supérieure, CNRS, 46 rue d’Ulm, 75005 Paris, France
Jon W. Johnson: University of Pittsburgh, A210 Langely Hall, Pittsburgh, Pennsylvania 15260, USA
Pierre Paoletti: Laboratoire de Neurobiologie, École Normale Supérieure, CNRS, 46 rue d’Ulm, 75005 Paris, France

Nature, 2009, vol. 459, issue 7247, 703-707

Abstract: NMDA receptors: NR2 subunits in control Members of the NMDA family of glutamate-gated ion channels, which play an important role in the control of synaptic plasticity and excitotoxic neuronal death in the brain, exhibit different opening probabilities and pharmacological profiles according to the NR2 subunit that they possess (NR2A-NR2D). Gielen et al. show that the degree of closure of the clamshell-like N-terminal domains of NR2 subunits determines this functional diversity.

Date: 2009
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DOI: 10.1038/nature07993

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