F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage

Manas K. Santra, Narendra Wajapeyee and Michael R. Green ()
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Manas K. Santra: Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Narendra Wajapeyee: Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Michael R. Green: Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA

Nature, 2009, vol. 459, issue 7247, 722-725

Abstract: DNA damage role of FBXO31 in cell growth arrest During the cellular response to DNA damage in eukaryotes, cell-cycle arrest is coordinated with DNA repair. Here the human F-box protein FBXO31 is shown to regulate the cell-cycle transition from G1 to S phase in response to DNA damage by mediating degradation of cyclin D1. Diverse DNA damaging agents result in increased FBXO31 levels, indicating that FBXO31 is a general mediator required to arrest cell growth after DNA damage.

Date: 2009
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DOI: 10.1038/nature08011

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