Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors

Jun K. Takeuchi () and Benoit G. Bruneau ()
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Jun K. Takeuchi: Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
Benoit G. Bruneau: Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA

Nature, 2009, vol. 459, issue 7247, 708-711

Abstract: Heart-cell generation The heart has little regenerative capacity after damage, so understanding the factors required to produce new cardiac myocytes is of great interest. Jun Takeuchi and Benoit Bruneau have investigated the minimal requirements for transdifferentiation of mouse mesoderm to cardiac myocytes, and find that two cardiac transcription factors and a cardiac-specific subunit of BAF chromatin-remodelling complexes are sufficient to direct differentiation of mouse mesoderm into beating cardiomyocytes. Addition of a further transcription factor promotes differentiation into contracting cardiomyocytes, and repression of noncardiac mesodermal genes. Defining the requirements for cardiac cellular differentiation may help in the long-term goal of regenerating cardiomyocytes for therapies.

Date: 2009
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DOI: 10.1038/nature08039

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