Specificity of sensory–motor connections encoded by Sema3e–Plxnd1 recognition

Eline Pecho-Vrieseling, Markus Sigrist, Yutaka Yoshida, Thomas M. Jessell () and Silvia Arber ()
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Eline Pecho-Vrieseling: Biozentrum, University of Basel, 4056 Basel, Switzerland, and Friedrich Miescher Institute for Biomedical Research
Markus Sigrist: Biozentrum, University of Basel, 4056 Basel, Switzerland, and Friedrich Miescher Institute for Biomedical Research
Yutaka Yoshida: Howard Hughes Medical Institute, Kavli Institute for Brain Science, Columbia University
Thomas M. Jessell: Howard Hughes Medical Institute, Kavli Institute for Brain Science, Columbia University
Silvia Arber: Biozentrum, University of Basel, 4056 Basel, Switzerland, and Friedrich Miescher Institute for Biomedical Research

Nature, 2009, vol. 459, issue 7248, 842-846

Abstract: Repellent recognition and synaptic specificity Reflex circuits are carefully and specifically formed between sensory and motor neurons based on the class of sensory cell and the muscle type innervated by the motor neuron. Pecho-Vrieseling et al. now report that this fine synaptic specificity is mediated by selective expression of Sema3e and PlexinD1 by specific motor and sensory neuron populations, respectively. Signalling cascades activated by these molecular repellents affected not only monosynaptic circuit anatomy, but also circuit function.

Date: 2009
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DOI: 10.1038/nature08000

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