Polar gradients of the DYRK-family kinase Pom1 couple cell length with the cell cycle

Sophie G. Martin () and Martine Berthelot-Grosjean
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Sophie G. Martin: Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Génopode Building, 1015 Lausanne, Switzerland
Martine Berthelot-Grosjean: Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Génopode Building, 1015 Lausanne, Switzerland

Nature, 2009, vol. 459, issue 7248, 852-856

Abstract: A time to divide Proliferating cells divide when they reach a certain size owing to regulated activity of cyclin-dependent kinase (Cdk1), but the links between Cdk1 regulators and mechanisms monitoring cell size have been elusive. Two papers in this issue describe how a fission yeast kinase Pom1, known to be a determinant of cell polarity, forms a polar gradient within the cell, which measures the length of the rod-shaped cells and induces cell division via negative regulation of the Cdk1 inhibitor Wee1.

Date: 2009
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DOI: 10.1038/nature08054

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