A spatial gradient coordinates cell size and mitotic entry in fission yeast

James B. Moseley (), Adeline Mayeux, Anne Paoletti and Paul Nurse
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James B. Moseley: The Rockefeller University, New York, New York 10065, USA
Adeline Mayeux: Institut Curie, Centre de Recherche and CNRS UMR144
Anne Paoletti: Institut Curie, Centre de Recherche and CNRS UMR144
Paul Nurse: The Rockefeller University, New York, New York 10065, USA

Nature, 2009, vol. 459, issue 7248, 857-860

Abstract: A time to divide Proliferating cells divide when they reach a certain size owing to regulated activity of cyclin-dependent kinase (Cdk1), but the links between Cdk1 regulators and mechanisms monitoring cell size have been elusive. Two papers in this issue describe how a fission yeast kinase Pom1, known to be a determinant of cell polarity, forms a polar gradient within the cell, which measures the length of the rod-shaped cells and induces cell division via negative regulation of the Cdk1 inhibitor Wee1.

Date: 2009
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DOI: 10.1038/nature08074

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