Genes that mediate breast cancer metastasis to the brain

Paula D. Bos, Xiang H.-F. Zhang, Cristina Nadal, Weiping Shu, Roger R. Gomis, Don X. Nguyen, Andy J. Minn, Marc J. van de Vijver, William L. Gerald, John A. Foekens and Joan Massagué ()
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Paula D. Bos: Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Xiang H.-F. Zhang: Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Cristina Nadal: Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Weiping Shu: Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Roger R. Gomis: Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Don X. Nguyen: Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Andy J. Minn: and Ludwig Center for Metastasis Research, The University of Chicago, Chicago, Illinois 60637, USA
Marc J. van de Vijver: Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
William L. Gerald: Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
John A. Foekens: Erasmus MC Rotterdam, Josephine Nefkens Institute and Cancer Genomics Centre
Joan Massagué: Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA

Nature, 2009, vol. 459, issue 7249, 1005-1009

Abstract: Brain metastasis in breast cancer Little is known about the mechanisms by which breast cancer cells metastasize to the brain. Bos et al. now identify three genes that are involved in this process. COX2 and HBEGF have previously been shown to also mediate breast cancer metastasis to the lung, suggesting common biological processes that regulate dissemination to these two organs. In addition, they find that ST6GALNAC5 is specifically involved in brain metastasis, by increasing the adhesion of breast cancer cells to the brain endothelium and migration through the blood–brain barrier.

Date: 2009
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DOI: 10.1038/nature08021

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