The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs

Michele Trabucchi, Paola Briata, MariaFlor Garcia-Mayoral, Astrid D. Haase, Witold Filipowicz, Andres Ramos (), Roberto Gherzi () and Michael G. Rosenfeld ()
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Michele Trabucchi: Howard Hughes Medical Institute, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, California 92093-0648, USA
Paola Briata: Istituto Nazionale per la Ricerca sul Cancro (IST), Largo R. Benzi, 10
MariaFlor Garcia-Mayoral: National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Astrid D. Haase: Friedrich Miescher Institute for Biomedical Research, PO Box 2543, 4002 Basel, Switzerland
Witold Filipowicz: Friedrich Miescher Institute for Biomedical Research, PO Box 2543, 4002 Basel, Switzerland
Andres Ramos: National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Roberto Gherzi: Istituto Nazionale per la Ricerca sul Cancro (IST), Largo R. Benzi, 10
Michael G. Rosenfeld: Howard Hughes Medical Institute, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, California 92093-0648, USA

Nature, 2009, vol. 459, issue 7249, 1010-1014

Abstract: Regulating the microRNA regulators As small RNAs exert profound effects on development and regulation of gene expression, their own expression must be similarly constrained to the right level in the right cell at the right time. A collaboration between the labs of Michael Rosenfeld and Witold Filipowicz reports that the RNA-binding protein KSRP (KH-type splicing regulatory protein) regulates the precursor processing of a subset of microRNAs. If this regulatory mechanism is disrupted, effects can be seen on proliferation, differentiation and apoptosis. Thus KSRP is involved in both mRNA turnover and in promoting mRNA expression. This work has uncovered a further level of complexity in the regulation of gene expression by mi-RNA.

Date: 2009
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DOI: 10.1038/nature08025

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