The Listeria transcriptional landscape from saprophytism to virulence

Alejandro Toledo-Arana, Olivier Dussurget, Georgios Nikitas, Nina Sesto, Hélène Guet-Revillet, Damien Balestrino, Edmund Loh, Jonas Gripenland, Teresa Tiensuu, Karolis Vaitkevicius, Mathieu Barthelemy, Massimo Vergassola, Marie-Anne Nahori, Guillaume Soubigou, Béatrice Régnault, Jean-Yves Coppée, Marc Lecuit, Jörgen Johansson and Pascale Cossart ()
Additional contact information
Alejandro Toledo-Arana: Institut Pasteur, Unité des Interactions Bactéries-Cellules
Olivier Dussurget: Institut Pasteur, Unité des Interactions Bactéries-Cellules
Georgios Nikitas: Inserm, U604, F-75015 Paris, France
Nina Sesto: Institut Pasteur, Unité des Interactions Bactéries-Cellules
Hélène Guet-Revillet: Institut Pasteur, Unité des Interactions Bactéries-Cellules
Damien Balestrino: Institut Pasteur, Unité des Interactions Bactéries-Cellules
Edmund Loh: Department of Molecular Biology,
Jonas Gripenland: Department of Molecular Biology,
Teresa Tiensuu: Department of Molecular Biology,
Karolis Vaitkevicius: Department of Molecular Biology,
Mathieu Barthelemy: Institut Pasteur, Génopole, Plate-forme 2, F-75015 Paris, France
Massimo Vergassola: Institut Pasteur, UP Génétique in silico, F-75015 Paris, France
Marie-Anne Nahori: Institut Pasteur, Unité des Interactions Bactéries-Cellules
Guillaume Soubigou: Institut Pasteur, Génopole, Plate-forme 2, F-75015 Paris, France
Béatrice Régnault: Institut Pasteur, Génopole, Plate-forme 2, F-75015 Paris, France
Jean-Yves Coppée: Institut Pasteur, Génopole, Plate-forme 2, F-75015 Paris, France
Marc Lecuit: Inserm, U604, F-75015 Paris, France
Jörgen Johansson: Department of Molecular Biology,
Pascale Cossart: Institut Pasteur, Unité des Interactions Bactéries-Cellules

Nature, 2009, vol. 459, issue 7249, 950-956

Abstract: Abstract The bacterium Listeria monocytogenes is ubiquitous in the environment and can lead to severe food-borne infections. It has recently emerged as a multifaceted model in pathogenesis. However, how this bacterium switches from a saprophyte to a pathogen is largely unknown. Here, using tiling arrays and RNAs from wild-type and mutant bacteria grown in vitro, ex vivo and in vivo, we have analysed the transcription of its entire genome. We provide the complete Listeria operon map and have uncovered far more diverse types of RNAs than expected: in addition to 50 small RNAs (

Date: 2009
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DOI: 10.1038/nature08080

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