A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

Philipp Niethammer (), Clemens Grabher, A. Thomas Look and Timothy J. Mitchison
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Philipp Niethammer: Harvard Medical School, Boston
Clemens Grabher: Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
A. Thomas Look: Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Timothy J. Mitchison: Harvard Medical School, Boston

Nature, 2009, vol. 459, issue 7249, 996-999

Abstract: Hydrogen peroxide role in wound detection A study of the role of hydrogen peroxide (H2O2) during the early events of wound responses in zebrafish larvae — a popular vertebrate model for inflammatory and regenerative responses to wounds — reveals a that tissue gradient of H2O2 forms in response to injury of the zebrafish tail fin. The gradient, made visible by the use of a genetically encoded fluorescent sensor protein, is created by the activity of dual oxidase (DUOX) and acts to attract leukocytes to the wound margin during the initial phase of inflammation. This is the first report of a role for H2O2 in signalling to leukocytes, in addition to its established role as an antiseptic.

Date: 2009
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DOI: 10.1038/nature08119

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