dUTP incorporation into genomic DNA is linked to transcription in yeast

Nayun Kim and Sue Jinks-Robertson ()
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Nayun Kim: Duke University Medical Center, Durham, North Carolina 27710, USA
Sue Jinks-Robertson: Duke University Medical Center, Durham, North Carolina 27710, USA

Nature, 2009, vol. 459, issue 7250, 1150-1153

Abstract: Genomic instability: high transcription rate means low fidelity When eukaryotic cells are transcribing at a high rate, it has been noted that genomic stability suffers, and mutational events are elevated. In this work, Nayun Kim and Sue Jinks-Robertson show that in yeast, highly transcribed DNA accumulates sites lacking a purine or pyrimidine base due to the removal of misincorporated uracil. This finding suggests that the fidelity of DNA synthesis can be affected by the level of transcription, and provides indirect evidence for nucleotide pool compartmentalization within the nucleus.

Date: 2009
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DOI: 10.1038/nature08033

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