Subcellular homeostasis of phytohormone auxin is mediated by the ER-localized PIN5 transporter

Jozef Mravec, Petr Skůpa, Aurélien Bailly, Klára Hoyerová, Pavel Křeček, Agnieszka Bielach, Jan Petrášek, Jing Zhang, Vassilena Gaykova, York-Dieter Stierhof, Petre I. Dobrev, Kateřina Schwarzerová, Jakub Rolčík, Daniela Seifertová, Christian Luschnig, Eva Benková, Eva Zažímalová, Markus Geisler and Jiří Friml ()
Additional contact information
Jozef Mravec: Ghent University
Petr Skůpa: Institute of Experimental Botany, ASCR, 165 02 Praha 6, Czech Republic
Aurélien Bailly: Zürich-Basel Plant Science Center, University of Zurich, Institute of Plant Biology, Molecular Plant Physiology
Klára Hoyerová: Institute of Experimental Botany, ASCR, 165 02 Praha 6, Czech Republic
Pavel Křeček: Institute of Experimental Botany, ASCR, 165 02 Praha 6, Czech Republic
Agnieszka Bielach: Ghent University
Jan Petrášek: Institute of Experimental Botany, ASCR, 165 02 Praha 6, Czech Republic
Jing Zhang: Ghent University
Vassilena Gaykova: Center for Plant Molecular Biology (ZMBP), University Tübingen
York-Dieter Stierhof: Center for Plant Molecular Biology (ZMBP), University Tübingen
Petre I. Dobrev: Institute of Experimental Botany, ASCR, 165 02 Praha 6, Czech Republic
Kateřina Schwarzerová: Faculty of Science, Charles University
Jakub Rolčík: Laboratory of Growth Regulators of the Institute of Experimental Botany, ASCR and Faculty of Science, Palacký University
Daniela Seifertová: Institute of Experimental Botany, ASCR, 165 02 Praha 6, Czech Republic
Christian Luschnig: University of Natural Resources and Applied Life Sciences - BOKU
Eva Benková: Ghent University
Eva Zažímalová: Institute of Experimental Botany, ASCR, 165 02 Praha 6, Czech Republic
Markus Geisler: Zürich-Basel Plant Science Center, University of Zurich, Institute of Plant Biology, Molecular Plant Physiology
Jiří Friml: Ghent University

Nature, 2009, vol. 459, issue 7250, 1136-1140

Abstract: Auxin and subcellular compartmentalization The plant hormone auxin is a key regulator of growth and development. The PINFORMED (PIN) efflux carriers are asymmetrically localized on the plasma membrane and mediate directional auxin transport between cells. In this study, Mravec et al. characterize an atypical member of the PIN family, PIN5, in Arabidopsis thaliana. They find that while it encodes a functional auxin transporter and is required for developmental processes, it does not mediate intercellular transport of auxin. Instead it is localized to the endoplasmic reticulum (ER) where it is presumed to mediate auxin flow from the cytosol to the lumen of the ER, thus regulating intracellular levels of the hormone. Sequence analysis and mutagenesis studies between plasma membrane and ER-localized PIN proteins suggest that only small motif changes were involved during diversification of these two protein classes. These results reveal a previously unsuspected way of regulating cellular homeostasis of signalling compounds by their subcellular compartmentalization.

Date: 2009
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DOI: 10.1038/nature08066

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