Yurt, Coracle, Neurexin IV and the Na+,K+-ATPase form a novel group of epithelial polarity proteins

Patrick Laprise, Kimberly M. Lau, Kathryn P. Harris, Nancy F. Silva-Gagliardi, Sarah M. Paul, Slobodan Beronja, Greg J. Beitel, C. Jane McGlade and Ulrich Tepass ()
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Patrick Laprise: University of Toronto, Toronto, Ontario M5S 3G5, Canada
Kimberly M. Lau: University of Toronto and The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Kathryn P. Harris: University of Toronto, Toronto, Ontario M5S 3G5, Canada
Nancy F. Silva-Gagliardi: University of Toronto and The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Sarah M. Paul: Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
Slobodan Beronja: University of Toronto, Toronto, Ontario M5S 3G5, Canada
Greg J. Beitel: Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
C. Jane McGlade: University of Toronto and The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Ulrich Tepass: University of Toronto, Toronto, Ontario M5S 3G5, Canada

Nature, 2009, vol. 459, issue 7250, 1141-1145

Abstract: Cell polarity step-by-step Polarization of cells is critical for the development of multicellular organisms and defects in this process contribute to several diseases. Generation of epithelial cell polarity in Drosophila involves polarity proteins such as Crumbs and partitioning defective. This study reports the identification of a novel protein pathway — involving Yurt, Coracle, Neurexin IV and the sodium-potassium pump — that is important for polarity formation during early embryogenesis in Drosophila and appears to be conserved in mammalian cells. This work suggests that polarity maintenance is a multi-step process, with different protein complexes involved at each step.

Date: 2009
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DOI: 10.1038/nature08067

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