Biomechanical forces promote embryonic haematopoiesis

Luigi Adamo, Olaia Naveiras, Pamela L. Wenzel, Shannon McKinney-Freeman, Peter J. Mack, Jorge Gracia-Sancho, Astrid Suchy-Dicey, Momoko Yoshimoto, M. William Lensch, Mervin C. Yoder, Guillermo García-Cardeña () and George Q. Daley ()
Additional contact information
Luigi Adamo: Center for Excellence in Vascular Biology, Boston, Massachusetts 02115, USA
Olaia Naveiras: Stem Cell Transplantation Program, Brigham and Women’s Hospital; Harvard Stem Cell Institute; Manton Center for Orphan Disease Research; Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
Pamela L. Wenzel: Stem Cell Transplantation Program, Brigham and Women’s Hospital; Harvard Stem Cell Institute; Manton Center for Orphan Disease Research; Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
Shannon McKinney-Freeman: Stem Cell Transplantation Program, Brigham and Women’s Hospital; Harvard Stem Cell Institute; Manton Center for Orphan Disease Research; Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
Peter J. Mack: Center for Excellence in Vascular Biology, Boston, Massachusetts 02115, USA
Jorge Gracia-Sancho: Center for Excellence in Vascular Biology, Boston, Massachusetts 02115, USA
Astrid Suchy-Dicey: Center for Excellence in Vascular Biology, Boston, Massachusetts 02115, USA
Momoko Yoshimoto: Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
M. William Lensch: Stem Cell Transplantation Program, Brigham and Women’s Hospital; Harvard Stem Cell Institute; Manton Center for Orphan Disease Research; Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
Mervin C. Yoder: Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Guillermo García-Cardeña: Center for Excellence in Vascular Biology, Boston, Massachusetts 02115, USA
George Q. Daley: Stem Cell Transplantation Program, Brigham and Women’s Hospital; Harvard Stem Cell Institute; Manton Center for Orphan Disease Research; Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA

Nature, 2009, vol. 459, issue 7250, 1131-1135

Abstract: Blood cells by heartbeat Following initiation of the heartbeat in vertebrate embryos, cells lining the aorta, the placental vessels and the umbilical and vitelline arteries begin to form haematopoietic cells. It has been suggested that biomechanical forces imposed on the vascular wall by the heartbeat, which sets up vascular flow and wall shear stress, could be the cue for the production of these early blood cells. Working with mouse embryonic stem cells differentiated in vitro and in mouse embryos, Adamo et al. show that exposure to fluid shear stress increases haematopoietic colony-forming potential and expression of haematopoietic markers both in vitro and in vivo. The confirmation of a link between the initiation of vascular flow and embryonic blood cell development provides new pointers for research on the production of haematopoietic progenitors for possible use in stem-cell-based therapies.

Date: 2009
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DOI: 10.1038/nature08073

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