Structural insight into the autoinhibition mechanism of AMP-activated protein kinase

Lei Chen, Zhi-Hao Jiao, Li-Sha Zheng, Yuan-Yuan Zhang, Shu-Tao Xie, Zhi-Xin Wang and Jia-Wei Wu ()
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Lei Chen: MOE Key Laboratory of Bioinformatics, Tsinghua University
Zhi-Hao Jiao: MOE Key Laboratory of Bioinformatics, Tsinghua University
Li-Sha Zheng: Institute of Biophysics and Graduate University, Chinese Academy of Sciences
Yuan-Yuan Zhang: MOE Key Laboratory of Bioinformatics, Tsinghua University
Shu-Tao Xie: MOE Key Laboratory of Bioinformatics, Tsinghua University
Zhi-Xin Wang: MOE Key Laboratory of Bioinformatics, Tsinghua University
Jia-Wei Wu: MOE Key Laboratory of Bioinformatics, Tsinghua University

Nature, 2009, vol. 459, issue 7250, 1146-1149

Abstract: Molecular mechanism AMPK autoinhibition mechanism AMPK (AMP-activated protein kinase) senses cellular energy status to maintain a balance between ATP production and consumption and has important roles in regulating cell growth and proliferation. Here, crystal structures of kinase and autoinhibitory domains from yeast AMPK subunits, together with biochemical data, reveal a mechanism for AMPK autoinhibition and suggest a model for allosteric activation by AMP.

Date: 2009
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DOI: 10.1038/nature08075

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