Genome-wide silencing in Drosophila captures conserved apoptotic effectors

Su Kit Chew, Po Chen, Nichole Link, Kathleen A. Galindo, Kristi Pogue and John M. Abrams ()
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Su Kit Chew: University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Po Chen: University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Nichole Link: University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Kathleen A. Galindo: University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Kristi Pogue: University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
John M. Abrams: University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA

Nature, 2009, vol. 460, issue 7251, 123-127

Abstract: Drosophila's conserved apoptosis factors A genome-wide silencing screen in Drosophila has identified a novel player in apoptosis. In their screen Chew et al. combined a library of double-stranded RNAs together with a chemical antagonist of Inhibitor of apoptosis proteins (IAPs). Thus they identified a set of validated targets necessary for death by several stimuli. Among these, Tango7 is identified as a novel effector for apoptosis in flies.

Date: 2009
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DOI: 10.1038/nature08087

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