Enhancing CD8 T-cell memory by modulating fatty acid metabolism

Erika L. Pearce, Matthew C. Walsh, Pedro J. Cejas, Gretchen M. Harms, Hao Shen, Li-San Wang, Russell G. Jones and Yongwon Choi ()
Additional contact information
Erika L. Pearce: Department of Pathology and Laboratory Medicine,
Matthew C. Walsh: Department of Pathology and Laboratory Medicine,
Pedro J. Cejas: Department of Pathology and Laboratory Medicine,
Gretchen M. Harms: Department of Pathology and Laboratory Medicine,
Hao Shen: Department of Microbiology,
Li-San Wang: Department of Pathology and Laboratory Medicine,
Russell G. Jones: McGill Cancer Centre, McGill University, Montreal, QC, H3G 1Y6, Canada
Yongwon Choi: Department of Pathology and Laboratory Medicine,

Nature, 2009, vol. 460, issue 7251, 103-107

Abstract: T-cell memory linked to energy metabolism CD8 T cells play a crucial role in immunity to infection and cancer. The predictable pattern of a CD8 T-cell response to infection is well established, but the underlying cellular mechanisms regulating the transition to memory remain undefined. Here, Pearce et al. show that metabolic conversion to catabolic pathways of energy generation is key to CD8 T-cell memory development in vivo. CD8 T cells switch from glucose metabolism to fatty acid metabolism as they differentiate into a 'memory' cell that can 'remember' past infections. The process is regulated by the tumour necrosis factor receptor-associated factor protein TRAF6.

Date: 2009
References: Add references at CitEc
Citations: View citations in EconPapers (4)

Downloads: (external link)
https://www.nature.com/articles/nature08097 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:460:y:2009:i:7251:d:10.1038_nature08097

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature08097

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().