The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting

Mary E. Donohoe, Susana S. Silva, Stefan F. Pinter, Na Xu and Jeannie T. Lee ()
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Mary E. Donohoe: Howard Hughes Medical Institute,
Susana S. Silva: Howard Hughes Medical Institute,
Stefan F. Pinter: Howard Hughes Medical Institute,
Na Xu: Howard Hughes Medical Institute,
Jeannie T. Lee: Howard Hughes Medical Institute,

Nature, 2009, vol. 460, issue 7251, 128-132

Abstract: Pluripotency and the X chromosome During both stem cell differentiation and X chromosome inactivation, the process that silences one female X chromosome to ensure gene dosage parity between the sexes, chromatin undergoes epigenetic reprogramming to lock in a new state. Reprogramming of differentiated cells into iPS cells also causes reactivation of the inactivated X chromosome, and it has been proposed that the pluripotency factor Oct4 links both processes. In this study, Donohoe et al. find that Oct4 regulates X-chromosome inactivation by triggering X-chromosome pairing and counting. Oct4 interacts with both noncoding RNA genes (Tsix and Xite) and proteins (Ctcf and Yy1). This work shows that there is a complex network involved in epigenetic reprogramming of the X chromosome in stem cells.

Date: 2009
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DOI: 10.1038/nature08098

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