A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells

Hitoshi Niwa (), Kazuya Ogawa, Daisuke Shimosato and Kenjiro Adachi
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Hitoshi Niwa: Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 6500047, Japan
Kazuya Ogawa: Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 6500047, Japan
Daisuke Shimosato: Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 6500047, Japan
Kenjiro Adachi: Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 6500047, Japan

Nature, 2009, vol. 460, issue 7251, 118-122

Abstract: Pluripotency factors dissected The cytokine leukaemia inhibitory factor (LIF) integrates signals into mouse embryonic stem cells to maintain pluripotency. The Jak-Stat3 pathway is known to mediate LIF signals, but it is not clear how these signals are linked to the core circuitry of pluripotency-associated transcription factors: Oct3/4, Sox2 and Nanog. Here Niwa et al. show that two LIF signalling pathways are each connected to the core circuitry by different transcription factors, thus there are parallel pathways controlling pluripotency. This paper is notable in that it is the one of the first, if not the first, to report a dissection of the functional hierarchy of transcription factors that maintains self-renewal of mouse embryonic stem cells.

Date: 2009
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DOI: 10.1038/nature08113

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