mTOR regulates memory CD8 T-cell differentiation

Koichi Araki, Alexandra P. Turner, Virginia Oliva Shaffer, Shivaprakash Gangappa, Susanne A. Keller, Martin F. Bachmann, Christian P. Larsen and Rafi Ahmed ()
Additional contact information
Koichi Araki: Emory Vaccine Center and Department of Microbiology and Immunology,
Alexandra P. Turner: Emory University School of Medicine, Atlanta, Georgia 30322, USA
Virginia Oliva Shaffer: Emory University School of Medicine, Atlanta, Georgia 30322, USA
Shivaprakash Gangappa: Emory University School of Medicine, Atlanta, Georgia 30322, USA
Susanne A. Keller: Cytos Biotechnology AG, Wagistrasse 25, 8952 Zürich-Schlieren, Switzerland
Martin F. Bachmann: Cytos Biotechnology AG, Wagistrasse 25, 8952 Zürich-Schlieren, Switzerland
Christian P. Larsen: Emory University School of Medicine, Atlanta, Georgia 30322, USA
Rafi Ahmed: Emory Vaccine Center and Department of Microbiology and Immunology,

Nature, 2009, vol. 460, issue 7251, 108-112

Abstract: T-cell memory regulation by mTOR mTOR, part of the PI3K–AKT–mTOR cell-signalling cascade and a target for the antitumour drug rapamycin, is identified here as a regulator of CD8 T-cell differentiation. Despite its primarily immunosuppressive activity, rapamycin can enhance immune responses to experimental vaccines in mice and monkeys. This counterintuitive finding points to the ability to increase the functional qualities of memory T cells as a potential way of enhancing the efficacy of vaccines against pathogens and cancers.

Date: 2009
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DOI: 10.1038/nature08155

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