Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages

Lei Bu, Xin Jiang, Silvia Martin-Puig, Leslie Caron, Shenjun Zhu, Ying Shao, Drucilla J. Roberts, Paul L. Huang, Ibrahim J. Domian and Kenneth R. Chien ()
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Lei Bu: Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza/CPZN 3208, 185 Cambridge Street, Boston, Massachusetts 02114, USA
Xin Jiang: Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza/CPZN 3208, 185 Cambridge Street, Boston, Massachusetts 02114, USA
Silvia Martin-Puig: Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza/CPZN 3208, 185 Cambridge Street, Boston, Massachusetts 02114, USA
Leslie Caron: Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza/CPZN 3208, 185 Cambridge Street, Boston, Massachusetts 02114, USA
Shenjun Zhu: Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza/CPZN 3208, 185 Cambridge Street, Boston, Massachusetts 02114, USA
Ying Shao: Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza/CPZN 3208, 185 Cambridge Street, Boston, Massachusetts 02114, USA
Drucilla J. Roberts: Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA
Paul L. Huang: Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza/CPZN 3208, 185 Cambridge Street, Boston, Massachusetts 02114, USA
Ibrahim J. Domian: Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza/CPZN 3208, 185 Cambridge Street, Boston, Massachusetts 02114, USA
Kenneth R. Chien: Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza/CPZN 3208, 185 Cambridge Street, Boston, Massachusetts 02114, USA

Nature, 2009, vol. 460, issue 7251, 113-117

Abstract: ISL1 progenitors are all heart Recent studies in mice identified multipotent embryonic ISL1+ (Islet 1 expressing) progenitor cells as capable of contributing to all of the major cell types in the heart. Human cardiogenesis is thought to involve more divergent pathways. Now a diverse set of human fetal ISL1+ cardiovascular progenitor populations with multipotent capability has been identified in the right atrium and outflow tract of the developing human heart. Transgenic and gene-targeting techniques applied to human embryonic stem cell lines show that purified populations of these primordial progenitors are capable of self-renewal and expansion prior to differentiation into the three major cell types in the heart — the cardiomyocytes, smooth muscle and endothelia. This has relevance for the production of human models for cardiovascular disease and potentially for human regenerative medicine.

Date: 2009
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DOI: 10.1038/nature08191

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