Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment

Olaia Naveiras, Valentina Nardi, Pamela L. Wenzel, Peter V. Hauschka, Frederic Fahey and George Q. Daley ()
Additional contact information
Olaia Naveiras: Brigham and Women’s Hospital; Harvard Stem Cell Institute; Manton Center for Orphan Diseases; Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
Valentina Nardi: Brigham and Women’s Hospital; Harvard Stem Cell Institute; Manton Center for Orphan Diseases; Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
Pamela L. Wenzel: Brigham and Women’s Hospital; Harvard Stem Cell Institute; Manton Center for Orphan Diseases; Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
Peter V. Hauschka: Harvard Medical School and School of Dental Medicine, Boston, Massachusetts, 02115, USA
Frederic Fahey: Children’s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
George Q. Daley: Brigham and Women’s Hospital; Harvard Stem Cell Institute; Manton Center for Orphan Diseases; Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA

Nature, 2009, vol. 460, issue 7252, 259-263

Abstract: Bad blood from fat cells Adult bone marrow contains numerous adipocytes, whose numbers correlate inversely with the haematopoietic activity. Disorders of excess haematopoiesis, such as pernicious anaemia and leukaemia, are typically accompanied by haematopoietic infiltration of the fatty marrow of the long bones. It has been unclear whether adipocytes participate in haematopoietic regulation or simply expand to fill marrow space. The answer appears to be that far from making up the numbers, fat cells play a critical physiological role in the bone marrow microenvironment. Experiments in mice show that adipocyte-rich marrow contains fewer blood-forming stem cells and progenitors than adipocyte-poor marrow. Genetically 'fat-free' mice and mice treated with a drug that blocks adipocyte production generated new blood cells more quickly than wild-type animals after a bone-marrow transplant, suggesting that blocking marrow adipogenesis may enhance haematopoietic recovery in clinical bone-marrow transplantation.

Date: 2009
References: Add references at CitEc
Citations: View citations in EconPapers (4)

Downloads: (external link)
https://www.nature.com/articles/nature08099 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:460:y:2009:i:7252:d:10.1038_nature08099

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature08099

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().