T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes

Greta Guarda, Catherine Dostert, Francesco Staehli, Katrin Cabalzar, Rosa Castillo, Aubry Tardivel, Pascal Schneider and Jürg Tschopp ()
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Greta Guarda: University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland
Catherine Dostert: University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland
Francesco Staehli: University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland
Katrin Cabalzar: University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland
Rosa Castillo: University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland
Aubry Tardivel: University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland
Pascal Schneider: University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland
Jürg Tschopp: University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland

Nature, 2009, vol. 460, issue 7252, 269-273

Abstract: Innate immunity: keeping control The innate immunity response must be kept under tight control, since a disproportionate response could be harmful to host tissues as well as to the invading pathogen. Guarda et al. this week report a role for activated T lymphocytes in exerting that control. Effector and memory CD4+ T cells are shown to inhibit NLRP1 and NLRP3 inflammasome activity

Date: 2009
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DOI: 10.1038/nature08100

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