CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation

Ivan Zanoni, Renato Ostuni, Giusy Capuano, Maddalena Collini, Michele Caccia, Antonella Ellena Ronchi, Marcella Rocchetti, Francesca Mingozzi, Maria Foti, Giuseppe Chirico, Barbara Costa, Antonio Zaza, Paola Ricciardi-Castagnoli and Francesca Granucci ()
Additional contact information
Ivan Zanoni: University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
Renato Ostuni: University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
Giusy Capuano: University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
Maddalena Collini: University of Milano-Bicocca, Piazza della Scienza 3, 20126 Milan, Italy
Michele Caccia: University of Milano-Bicocca, Piazza della Scienza 3, 20126 Milan, Italy
Antonella Ellena Ronchi: University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
Marcella Rocchetti: University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
Francesca Mingozzi: University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
Maria Foti: University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
Giuseppe Chirico: University of Milano-Bicocca, Piazza della Scienza 3, 20126 Milan, Italy
Barbara Costa: University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
Antonio Zaza: University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
Paola Ricciardi-Castagnoli: University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
Francesca Granucci: University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy

Nature, 2009, vol. 460, issue 7252, 264-268

Abstract: CD14 in apoptosis This study defines a previously unknown specific role for CD14, a molecule that, in conjunction with other receptors, recognizes the lipopolysaccharide (LPS) of bacterial cell wall. CD14 is shown to regulate dendritic cell apoptosis after LPS stimulation via a PLC-γ2–Ca2+–NFAT-dependent pathway. This finding significantly advances the knowledge of the molecular events occurring during the initial phases of defence to bacterial infections.

Date: 2009
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DOI: 10.1038/nature08118

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